Alpha One is a 1999 Ford Explorer, with modifications done to allow it to work in a first response role. It has a strobe lightbar package, wig-wag headlights and strobes. It carries the same walk-in equipment that the ambulances carry, and some additional immobilization gear. These units stock some bulk amounts of drugs and supplies so they can stay out and work consecutive calls if necessary.

Florence County EMS Alpha One is stationed at 527 S. Church St, Florence. Currently, this unit is only staffed when the need arises for additional manpower from the Special Operations Team or other called in personnel.

Quick Response Vehicle (QRV) -- An emergency response medical unit that is equivalent to a standard EMS response unit with only two differences: one paramedic staffs the vehicle, not two; and the QRV has no patient transport capability. This unit is dispatched to scenes where no transport is expected, or to assist a responding ambulance.